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USC-OGP 2-DE database

Two-dimensional polyacrylamide gel electrophoresis database
USC-OGP 2-DE database 
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Searching in 'USC-OGP 2-DE database' for entry matching: SETD2_HUMAN




USC-OGP 2-DE database:  SETD2_HUMAN

SETD2_HUMAN


General information about the entry
View entry in simple text format
Entry nameSETD2_HUMAN
Primary accession numberQ9BYW2
integrated into USC-OGP 2-DE database on January 17, 2017 (release 1)
2D Annotations were last modified onJanuary 17, 2017 (version 1)
General Annotations were last modified on April 5, 2017 (version 2)
Name and origin of the protein
DescriptionRecName: Full=Histone-lysine N-methyltransferase SETD2; EC=2.1.1.43; AltName: Full=HIF-1; AltName: Full=Huntingtin yeast partner B; AltName: Full=Huntingtin-interacting protein 1; Short=HIP-1; AltName: Full=Huntingtin-interacting protein B; AltName: Full=Lysine N-methyltransferase 3A; AltName: Full=SET domain-containing protein 2; Short=hSET2; AltName: Full=p231HBP;.
Gene nameName=SETD2
Synonyms=HIF1, HYPB, KIAA1732, KMT3A, SET2
ORFNames=HSPC069
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   2D GEL CHARACTERIZATION
Author 1., Author 2.
Submitted (Mar-2011) to Current
2D PAGE maps for identified proteins
How to interpret a protein

PLATELET_5-6 {PLATELET 5-6}
Homo sapiens (Human)
PLATELET_5-6
  map experimental info 		 
PLATELET_5-6

MAP LOCATIONS:
pI=5.45; Mw=32965

Cross-references
UniProtKB/Swiss-ProtQ9BYW2; SETD2_HUMAN.



2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 0.0
Entry nameSETD2_HUMAN
Primary accession numberQ9BYW2
Secondary accession number(s) O75397 O75405 Q17RW8 Q5BKS9 Q5QGN2 Q69YI5 Q6IN64 Q6ZN53 Q6ZS25 Q8N3R0 Q8TCN0 Q9C0D1 Q9H696 Q9NZW9
Sequence was last modified on May 18, 2010 (version 3)
Annotations were last modified on March 15, 2017 (version 145)
Name and origin of the protein
DescriptionRecName: Full=Histone-lysine N-methyltransferase SETD2; EC=2.1.1.43; AltName: Full=HIF-1; AltName: Full=Huntingtin yeast partner B; AltName: Full=Huntingtin-interacting protein 1; Short=HIP-1; AltName: Full=Huntingtin-interacting protein B; AltName: Full=Lysine N-methyltransferase 3A; AltName: Full=SET domain-containing protein 2; Short=hSET2; AltName: Full=p231HBP;
Gene nameName=SETD2
Synonyms=HIF1, HYPB, KIAA1732, KMT3A, SET2
ORFNames=HSPC069
Encoded onName=SETD2; Synonyms=HIF1, HYPB, KIAA1732, KMT3A, SET2; ORFNames=HSPC069
Keywords3D-structure; Activator; Alternative splicing; Autism spectrum disorder; Chromatin regulator; Chromosome; Coiled coil; Complete proteome; Disease mutation; Isopeptide bond; Mental retardation; Methyltransferase; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; S-adenosyl-L-methionine; Transcription; Transcription regulation; Transferase; Ubl conjugation.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLAC094020; -; NOT_ANNOTATED_CDS; Genomic_DNA
EMBLAC127430; -; NOT_ANNOTATED_CDS; Genomic_DNA
EMBLAK026125; BAB15367.1; ALT_SEQ; mRNA
EMBLAK127782; BAC87131.1; ALT_INIT; mRNA
EMBLAK131371; BAD18522.1; -; mRNA
EMBLAL713692; CAD28492.1; -; mRNA
EMBLAL831959; CAD38601.2; ALT_INIT; mRNA
EMBLAL833394; CAH10589.1; -; mRNA
EMBLAJ238403; CAC28349.1; ALT_SEQ; mRNA
EMBLBC072440; AAH72440.1; ALT_SEQ; mRNA
EMBLBC090954; AAH90954.1; -; mRNA
EMBLBC117162; AAI17163.1; ALT_INIT; mRNA
EMBLBC117164; AAI17165.1; ALT_INIT; mRNA
EMBLAY576987; AAT77612.1; ALT_INIT; mRNA
EMBLAY576988; AAT77613.1; ALT_INIT; mRNA
EMBLAB051519; BAB21823.2; -; mRNA
EMBLAF161554; AAF29041.1; ALT_FRAME; mRNA
EMBLAF049103; AAC26194.1; -; mRNA
EMBLAF049610; AAC26846.1; -; mRNA
CCDSCCDS2749.2; -. [Q9BYW2-1]; .
RefSeqNP_054878.5; NM_014159.6. [Q9BYW2-1]; .
UniGeneHs.517941; -; .
PDB2A7O; NMR; -; A=2457-2564
PDB2MDC; NMR; -; A=2385-2430
PDB2MDI; NMR; -; A=2377-2430
PDB2MDJ; NMR; -; A=2377-2430
PDB4FMU; X-ray; 2.10 A; A=1434-1711
PDB4H12; X-ray; 1.99 A; A=1434-1711
PDB5JJY; X-ray; 2.05 A; A=1434-1711
PDB5JLB; X-ray; 1.50 A; A=1434-1711
PDB5JLE; X-ray; 2.40 A; A=1434-1711
PDB5LSS; X-ray; 1.79 A; A=1433-1711
PDB5LSX; X-ray; 2.90 A; A=1433-1711
PDB5LSY; X-ray; 1.62 A; A=1433-1711
PDB5LSZ; X-ray; 1.62 A; A=1433-1711
PDB5LT6; X-ray; 2.05 A; A/B=1433-1711
PDB5LT7; X-ray; 1.51 A; A=1433-1711
PDB5LT8; X-ray; 1.57 A; A=1433-1711
PDBsum2A7O; -; .
PDBsum2MDC; -; .
PDBsum2MDI; -; .
PDBsum2MDJ; -; .
PDBsum4FMU; -; .
PDBsum4H12; -; .
PDBsum5JJY; -; .
PDBsum5JLB; -; .
PDBsum5JLE; -; .
PDBsum5LSS; -; .
PDBsum5LSX; -; .
PDBsum5LSY; -; .
PDBsum5LSZ; -; .
PDBsum5LT6; -; .
PDBsum5LT7; -; .
PDBsum5LT8; -; .
ProteinModelPortalQ9BYW2; -; .
SMRQ9BYW2; -; .
BioGrid118845; 36; .
IntActQ9BYW2; 15; .
MINTMINT-1537591; -; .
STRING9606.ENSP00000386759; -; .
BindingDBQ9BYW2; -; .
ChEMBLCHEMBL3108647; -; .
iPTMnetQ9BYW2; -; .
PhosphoSitePlusQ9BYW2; -; .
BioMutaSETD2; -; .
DMDM296452963; -; .
OGPQ9BYW2; -; .
EPDQ9BYW2; -; .
MaxQBQ9BYW2; -; .
PaxDbQ9BYW2; -; .
PeptideAtlasQ9BYW2; -; .
PRIDEQ9BYW2; -; .
EnsemblENST00000409792; ENSP00000386759; ENSG00000181555. [Q9BYW2-1]; .
GeneID29072; -; .
KEGGhsa:29072; -; .
UCSCuc003cqs.4; human. [Q9BYW2-1]; .
CTD29072; -; .
DisGeNET29072; -; .
GeneCardsSETD2; -; .
H-InvDBHIX0021942; -; .
H-InvDBHIX0163343; -; .
HGNCHGNC:18420; SETD2; .
HPAHPA042451; -; .
MalaCardsSETD2; -; .
MIM144700; phenotype; .
MIM612778; gene; .
MIM616831; phenotype; .
neXtProtNX_Q9BYW2; -; .
OpenTargetsENSG00000181555; -; .
Orphanet821; Sotos syndrome; .
PharmGKBPA143485612; -; .
eggNOGKOG4442; Eukaryota; .
eggNOGCOG2940; LUCA; .
GeneTreeENSGT00780000121845; -; .
HOVERGENHBG093939; -; .
InParanoidQ9BYW2; -; .
KOK11423; -; .
OMAFIGHDSH; -; .
OrthoDBEOG091G040P; -; .
PhylomeDBQ9BYW2; -; .
TreeFamTF106477; -; .
BRENDA2.1.1.43; 2681; .
ReactomeR-HSA-3214841; PKMTs methylate histone lysines; .
SignaLinkQ9BYW2; -; .
SIGNORQ9BYW2; -; .
ChiTaRSSETD2; human; .
EvolutionaryTraceQ9BYW2; -; .
GeneWikiSETD2; -; .
GenomeRNAi29072; -; .
PROPR:Q9BYW2; -; .
ProteomesUP000005640; Chromosome 3; .
BgeeENSG00000181555; -; .
CleanExHS_SETD2; -; .
ExpressionAtlasQ9BYW2; baseline; .
GenevisibleQ9BYW2; HS; .
GOGO:0005694; C:chromosome; IEA:UniProtKB-SubCell; .
GOGO:0005654; C:nucleoplasm; TAS:Reactome; .
GOGO:0046975; F:histone methyltransferase activity (H3-K36 specific); IDA:HGNC; .
GOGO:0018024; F:histone-lysine N-methyltransferase activity; IDA:UniProtKB; .
GOGO:0001525; P:angiogenesis; IEA:Ensembl; .
GOGO:0035441; P:cell migration involved in vasculogenesis; IEA:Ensembl; .
GOGO:0060977; P:coronary vasculature morphogenesis; IEA:Ensembl; .
GOGO:0048701; P:embryonic cranial skeleton morphogenesis; IEA:Ensembl; .
GOGO:0060669; P:embryonic placenta morphogenesis; IEA:Ensembl; .
GOGO:0030900; P:forebrain development; IEA:Ensembl; .
GOGO:0097676; P:histone H3-K36 dimethylation; IDA:HGNC; .
GOGO:0097198; P:histone H3-K36 trimethylation; IDA:UniProtKB; .
GOGO:0048332; P:mesoderm morphogenesis; IEA:Ensembl; .
GOGO:0006298; P:mismatch repair; IMP:UniProtKB; .
GOGO:0001763; P:morphogenesis of a branching structure; IEA:Ensembl; .
GOGO:0001843; P:neural tube closure; IEA:Ensembl; .
GOGO:0034728; P:nucleosome organization; IMP:UniProtKB; .
GOGO:0060039; P:pericardium development; IEA:Ensembl; .
GOGO:0010793; P:regulation of mRNA export from nucleus; IMP:UniProtKB; .
GOGO:0006355; P:regulation of transcription; DNA-templated; IEA:UniProtKB-KW
GOGO:0048864; P:stem cell development; IEA:Ensembl; .
GOGO:0006368; P:transcription elongation from RNA polymerase II promoter; IMP:UniProtKB; .
InterProIPR006560; AWS_dom; .
InterProIPR003616; Post-SET_dom; .
InterProIPR001214; SET_dom; .
InterProIPR013257; SRI; .
InterProIPR001202; WW_dom; .
PfamPF00856; SET; 1; .
PfamPF08236; SRI; 1; .
PfamPF00397; WW; 1; .
SMARTSM00570; AWS; 1; .
SMARTSM00508; PostSET; 1; .
SMARTSM00317; SET; 1; .
SMARTSM00456; WW; 1; .
SUPFAMSSF51045; SSF51045; 1; .
PROSITEPS51215; AWS; 1; .
PROSITEPS50868; POST_SET; 1; .
PROSITEPS50280; SET; 1; .
PROSITEPS01159; WW_DOMAIN_1; 1; .
PROSITEPS50020; WW_DOMAIN_2; 1; .


USC-OGP 2-DE database image

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Database constructed and maintained by Angel Garcia, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server

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